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As scientists learned more, it was understood that these proteins and others were part of a broader class of proteins involved in self-defense, and should be called "cytokines".M) concentrations that can increase up to 1,000-fold during trauma or infection.Further, as molecules, cytokines are not limited to their immunomodulatory role.Cytokines have been classed as lymphokines, interleukins, and chemokines, based on their presumed function, cell of secretion, or target of action.Cytokines are a broad and loose category of small proteins (~5–20 k Da) that are important in cell signalling.Their release has an effect on the behavior of cells around them.Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors but generally not hormones or growth factors (despite some overlap in the terminology).

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They are important in health and disease, specifically in host responses to infection, immune responses, inflammation, trauma, sepsis, cancer, and reproduction.

Cytokines also play a role in anti-inflammatory pathways and are a possible therapeutic treatment for pathological pain from inflammation or peripheral nerve injury.