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A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.
Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.
Claritin-D 24 hour (10mg loratadine 240mg psuedophedrine) Dosing (Adult): one tablet po qd. Approval: 2013 Mechanism of Action: Carbinoxamine is an H1 receptor antagonist (antihistamine) that exhibits anticholinergic (drying) and sedative properties.
Claritin-D 24 Hour Extended Release Tablets should generally be avoided in patients with hepatic insufficiency. Antihistamines compete with histamine for receptor sites on effector cells.
[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.
Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.
Desloratadine inhibited histamine release from human mast cells in vitro.
These findings suggest that chronic kratom administration does...
Mechanism of Action Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects.