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Sigma receptor activation by methamphetamine promotes methamphetamine-induced neurotoxicity by facilitating hyperthermia, increasing dopamine synthesis and release, influencing microglial activation, and modulating apoptotic signaling cascades and the formation of reactive oxygen species.
A moderate overdose of methamphetamine may induce symptoms such as: abnormal heart rhythm, confusion, difficult and/or painful urination, high or low blood pressure, high body temperature, over-active and/or over-responsive reflexes, muscle aches, severe agitation, rapid breathing, tremor, urinary hesitancy, and an inability to pass urine.
In low doses, methamphetamine can elevate mood, increase alertness, concentration and energy in fatigued individuals, reduce appetite, and promote weight loss.
At higher doses, it can induce psychosis, breakdown of skeletal muscle, seizures and bleeding in the brain.
As dry mouth is also a common side effect of other stimulants, which are not known to contribute severe tooth decay, many researchers suggest that methamphetamine associated tooth decay is more due to users' other choices.
They suggest the side effect has been exaggerated and stylized to create a stereotype of current users to deter new ones.
a high likelihood that withdrawal symptoms will occur when methamphetamine use ceases).
Methamphetamine belongs to the substituted phenethylamine and substituted amphetamine chemical classes.